Notch-RBP-J signaling regulates the mobilization and function of endothelial progenitor cells by dynamic modulation of CXCR4 expression in mice.
Bone marrow (BM)-derived 730 sunken lake road endothelial progenitor cells (EPC) have therapeutic potentials in promoting tissue regeneration, but how these cells are modulated in vivo has been elusive.Here, we report that RBP-J, the critical transcription factor mediating Notch signaling, modulates EPC through CXCR4.In a mouse partial hepatectomy